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M9470039.TXT
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1994-07-02
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Document 0039
DOCN M9470039
TI Intravitreal use of foscarnet: retinotoxicity of repeated injections in
the rabbit eye.
DT 9409
AU Turrini B; Tognon MS; De Caro G; Secchi AG; Institute of Ophthalmology,
University of Padua, School of; Medicine, Italy.
SO Ophthalmic Res. 1994;26(2):110-5. Unique Identifier : AIDSLINE
MED/94255196
AB Cytomegalovirus retinitis is the most frequent ocular opportunistic
infection in AIDS patients. In selected cases intravitreal injections of
foscarnet may be the sole therapeutic possibility. The retinal toxicity
of the drug, however, has not yet been thoroughly investigated. Our
present study in the rabbit eye concerns the retinal toxicity of 2, 4,
and 6 intravitreal injections of 3.6 mg of foscarnet, using
ophthalmoscopy, histology and electrophysiology to evaluate retinal
damage. The results show that foscarnet may be employed intravitreally
without substantial damage to the retina, but only in short courses of
injections when no other therapeutic possibility may be utilized.
DE Animal Drug Administration Schedule Electroretinography/DRUG EFFECTS
Female Foscarnet/ADMINISTRATION & DOSAGE/*TOXICITY Fundus Oculi Male
Ophthalmoscopy Rabbits Retina/*DRUG EFFECTS/PATHOLOGY/PHYSIOPATHOLOGY
Retinitis/CHEMICALLY INDUCED/PATHOLOGY/PHYSIOPATHOLOGY Support,
Non-U.S. Gov't Vitreous Body JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).